Part 4

This is the final of four reports on the 8th Annual World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease (WCIRDC), 4–6 November 2010, Los Angeles, California.

Stephen Daniels (Denver, CO) discussed the influence of obesity and insulin resistance on the heart and vasculature during childhood. In a classic epidemiologic study comparing inactive bus drivers with physically active bus conductors, the former had greater waist circumference and higher risk of both total and fatal myocardial infarction ( 1). Daniels noted the substantial increase in severe obesity in school-age children over the past few decades and suggested that there is evidence of a relationship between childhood obesity and adult obesity ( 2) and that childhood obesity is associated with elevation in cardiovascular risk factors, implying that childhood obesity contributes to adult cardiovascular disease (CVD). A dramatic example is the increasing prevalence of childhood diabetes. Type 2 diabetes is certainly a cardiovascular risk factor in adults, with lag in adults of 10–15 years from diagnosis of diabetes to CVD, typically preceded by a 5- to 10-year lag from onset of hyperglycemia to diagnosis of diabetes. A similar time course for individuals developing type 2 diabetes in adolescence would begin to cause cardiovascular morbidity in their fourth decade of life. On a population level, both mean blood pressure and the prevalence of hypertension have increased, again with circumstantial evidence of a relationship with obesity. Both adiposity and blood pressure determine left ventricular mass in childhood ( 3, 4), with all these factors correlating with autopsy findings of early atherosclerosis in children ( 5), with evidence of calcification of the coronary arteries ( 6), and in an epidemiologic study of 276,835 Danish school children, with demonstration of a significant relationship between childhood BMI and CVD in adulthood ( 7). Potential mechanisms of the association of CVD with obesity include …

[Full Text of this Article]

What’s this?

« Previous | Next Article »Table of Contents

Similar Posts:

• Liraglutide Treatment in a Patient With HIV and Uncontrolled Insulin-Treated Type 2 Diabetes
• Metabolic Syndrome Linked to Inflammation
• Life Expectancy Improves for Type 1 Diabetics
• Obesity Hits Girls’ Blood Pressure Harder Than Boys’
• In a new post-hoc analysis, significantly more patients achieved blood sugar goals with JANUMET

You can leave a response, or trackback from your own site.